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Chimeric Cytokine Receptor Capable of Converting Immunosuppressive Signal to Immunostimmulatory Signal Immune Cell Expressing the Same and Anti-Cancer Use Thereof
Chimeric Cytokine Receptor Capable of Converting Immunosuppressive Signal to Immunostimmulatory Signal Immune Cell Expressing the Same and Anti-Cancer Use Thereof
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机译:能够将免疫抑制信号转换为表达其相同和抗癌的免疫抑制信号免疫细胞的嵌合细胞因子受体
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摘要
The present invention relates to a chimeric cytokine receptor capable of converting an immunosuppressive signal into an immune activation signal, an immune cell expressing the same, and a pharmaceutical composition for the treatment of cancer comprising the immune cell as an active ingredient. Immune cells expressing the chimeric cytokine receptor of the present invention can exert a stronger cytotoxic effect on cancer by converting an immunosuppressive signal into an immune activation signal in a microtumor environment in which immunosuppressive cytokines exist. Immune cells expressing the chimeric cytokine receptor of the present invention can be used as a cell therapy for cancer treatment.
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