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METHOD FOR PREDICTING CELL SPATIAL RELATION BASED ON SINGLE-CELL TRANSCRIPTOME SEQUENCING DATA
METHOD FOR PREDICTING CELL SPATIAL RELATION BASED ON SINGLE-CELL TRANSCRIPTOME SEQUENCING DATA
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机译:基于单细胞转录组测序数据预测细胞空间关系的方法
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摘要
A method for predicting the cell spatial relation based on single-cell transcriptome sequencing data, comprising: obtaining a probability matrix P of a cell-cell interaction strength matrix A based on single-cell transcriptome sequencing data; reconstructing, according to the obtained probability matrix P of the cell-cell interaction strength matrix A, a three-dimensional spatial structure in which cells interact with each other; and for each cell in the reconstructed three-dimensional spatial structure in which cells interact with each other, determining the average intercellular distance threshold for each cell to interact with h cells to obtain an intercellular interaction network. The method requires only the single-cell transcriptome sequencing data to predict the interaction of the cells in three-dimensional space, which breaks limitations in the prior art that the cell spatial relation is required to be obtained by imaging.
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