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Assessing Transplant Rejection Status by Analysis of T-Cell Receptor Subunit Repertoire Diversity
Assessing Transplant Rejection Status by Analysis of T-Cell Receptor Subunit Repertoire Diversity
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机译：通过分析T细胞受体亚基曲目分集评估移植抑制状态
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摘要
Disclosed are novel methods of assessing transplant rejection status in a transplant recipient, such as a kidney transplant recipient. The diagnostic method identifies stable subjects, subjects undergoing cell mediated rejection processes, and subjects undergoing antibody mediated rejection processes using measurement of TCR subunit repertoire diversity. The proportion of unique TCR alpha and beta subunit sequences to total unique TCR subunit sequences (total sequences for alpha, beta, delta, and gamma subunits) provides a diagnostic measure that can identify stable subjects, subjects undergoing cell mediated rejection processes, and subjects undergoing antibody mediated rejection processes. Methods of treatment include administration of a suitable treatment if antibody mediated rejection or cell mediated rejection is detected.
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