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Emulsifier, aqueous emulsifier solution, method for producing aqueous emulsifier solution, and oil dispersion in water

机译:乳化剂,水性乳化剂溶液,生产乳化剂溶液的方法,以及水中的油分散体

摘要

PROBLEM TO BE SOLVED: To provide an emulsifier capable of easily dispersing a water-insoluble or sparingly water-soluble organic drug in an aqueous medium containing water as a main component to prepare an oil-in-water dispersion having excellent dispersion stability. An emulsifier used for dispersing a water-insoluble or sparingly water-soluble organic drug in water, and a polymer satisfying the following requirements [1] to [4]. [1] AB block copolymer. [2] The polymer block A is a polymer block having a glass transition temperature of 0 ° C. or lower and occupying 10 to 40% by mass of the AB block copolymer. [3] A water-soluble or water-soluble polymer block in which the polymer block B contains 50 to 100% by mass of a structural unit (B-1) derived from a monomer (B-1) such as polyethylene glycol monomethyl ether methacrylate. be. [4] The number average molecular weight is 5,000 to 20,000, and the molecular weight distribution is 1.5 or less. [Selection diagram] None
机译:要解决的问题:提供一种乳化剂,其能够在含水的水性介质中容易地将水不溶性或微弱的水溶性有机药物分散为主要成分,以制备具有优异的分散稳定性的水式分散体。 用于在水中分散水不溶性或稀疏水溶性有机药物的乳化剂,以及满足以下要求的聚合物[1]至[4]。 [1] AB嵌段共聚物。 [2]聚合物嵌段A是具有0℃或更低的玻璃化转变温度的聚合物嵌段,占据10至40质量%的AB嵌段共聚物。 [3]一种水溶性或水溶性聚合物嵌段,其中聚合物嵌段B含有50至100质量%的结构单元(B-1)衍生自单体(B-1),例如聚乙二醇单甲基醚 甲基丙烯酸酯。 是。 [4]数均分子量为5,000至20,000,分子量分布为1.5或更小。 [选择图]无

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