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A method for analyzing a resistance of targeted anti-cancer therapy and identifying a combination target to overcome the resistance using network simulation
A method for analyzing a resistance of targeted anti-cancer therapy and identifying a combination target to overcome the resistance using network simulation
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机译：一种分析靶向抗癌治疗的抗性和识别组合目标的方法，使用网络仿真克服电阻
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摘要
We present a method to determine a perturbed combinatorial target node in combination with a perturbed target node in a cancer signaling network. This method calculates the change in the activity of the candidate node based on the difference value between the first activity and the second activity, which is the activity of the candidate node of the signaling network before and after perturbation of the target node, and based on a score proportional to the activity change to determine whether to determine the candidate node as a combined target node that perturbs with the target node.
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