首页> 外国专利> METHOD FOR SYNTHESIS OF NOVEL CHIRAL LIGAND, METAL CHELATE, VARIOUS UNNATURAL AMINO ACIDS, MARAVIROC AND MAIN INTERMEDIATE COMPOUNDS THEREOF

METHOD FOR SYNTHESIS OF NOVEL CHIRAL LIGAND, METAL CHELATE, VARIOUS UNNATURAL AMINO ACIDS, MARAVIROC AND MAIN INTERMEDIATE COMPOUNDS THEREOF

机译：合成新型手性配体，金属螯合物，各种非自然氨基酸，马来残治及其主要中间体化合物的方法

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FIELD: chemistry.;SUBSTANCE: invention relates to a method of synthesis of a novel quaternary carbon chiral ligand. Method of synthesis includes a step for synthesis of compound of formula IV,; ,;where n is integer from 1 to 4; R is selected from a group consisting of C1-C4-alkyl, C1-C4-halogenalkyl; R₁ is selected from a group consisting of C1-C4-alkyl, C1-C4-halogenalkyl and unsubstituted or substituted phenyl, where substituted phenyl means that phenyl has 1–5 substitutes, and each substitute is independently selected from a group consisting of halogen; R₂ is selected from a group consisting of H, halogen and C1-C4-alkyl; R₃ is selected from a group consisting of C1-C4-alkyl, unsubstituted or substituted phenyl and - (C1-C4 alkylene) - (unsubstituted or substituted phenyl), where substituted phenyl means that phenyl has 1–5 substitutes, and each substitute is independently selected from a group consisting of halogen, C1-C4-alkyl and C1-C4-halogenalkyl. Also disclosed are a method of producing an alpha-amino acid, an alpha-substituted beta-amino acid and a beta-substituted beta-amino acid, an intermediate compound Maraviroc, a chiral ligand having a structure of formula IV, a method for synthesis of an intermediate compound Maraviroc, method of synthesis of a non-natural amino acid, a method for synthesis of a basic intermediate compound of Maraviroc and a method for synthesis of Maraviroc.;EFFECT: invention enables to optimize the Maraviroc synthesis scheme and improve optical purity of the product.;9 cl, 124 ex

机译：田地：化学。物质：发明涉及一种新型季碳手性配体的合成方法。合成方法包括合成式IV化合物的步骤，; ，其中n为1到4的整数; R选自由C1-C4-烷基，C1-C4-卤代烷基组成的组。 R _{1 选自C1-C4-烷基，C1-C4-卤烷基和未取代的或取代的苯基，其中取代的苯基是指苯基具有1-5个替代品，并且每个替代物独立选自由卤素组成的组; r _{2 选自由H，卤素和C1-C4-烷基组成的组; R _{3 选自C1-C4-烷基，未取代或取代的苯基和 - （C1-C4亚烷基） - （未取代的或取代的苯基），其中取代的苯基意味着苯基具有1 -5替代物，并且每个替代物独立地选自卤素，C1-C4-烷基和C1-C4-卤代烷基。还公开了一种制备α-氨基酸，α-取代的β-氨基酸和β取代的β-氨基酸的方法，中间体化合物Maraviroc，具有式IV结构的手性配体，一种合成方法中间体化合物马拉维毒，非天然氨基酸的合成方法，合成马拉西吡普基本中间体化合物的方法及其合成Maraviroc。;效果：发明能够优化Maraviroc合成方案并改善光学产品的纯度。; 9 cl，124 ex}}}

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公开/公告号RU2727723C9

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公开/公告日2021-08-18

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申请/专利号RU20190112277
发明设计人 LIU HONG (CN);WANG JIANG (CN);ZHOU SHENGBIN (CN);PENG PANFENG (CN);NIAN YONG (CN);WANG SHUNI (CN);SHU SHUANGJIE (CN);SHEN HAO (CN);JIANG HUALIANG (CN);CHEN KAIXIAN (CN);
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申请日2017-09-19
分类号C07D207/16;C07D409/12;C07D401/04;C07F15/04;C07C227/34;C07C229/34;
国家 RU
入库时间 2022-08-24 20:39:13

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