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ADMINISTRATIVE FACTORS PREPARED FOR DISPOSAL IN THE FIELD OF THE STANDARD TREATY UNDER CONCLUSION OF A CLOSURE MEDICINAL PRODUCT LEGISLATION
ADMINISTRATIVE FACTORS PREPARED FOR DISPOSAL IN THE FIELD OF THE STANDARD TREATY UNDER CONCLUSION OF A CLOSURE MEDICINAL PRODUCT LEGISLATION
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机译：根据结束药品立法，在标准条约的领域准备出售的行政因素
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摘要
Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and/or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and/or degraded within the GI tract.
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