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ACTIVELY TRANSPORTED AND PROTEASE-RESISTANT PEPTIDES AS BBB SHUTTLES AND SHUTTLE-CARGO CONSTRUCTS
ACTIVELY TRANSPORTED AND PROTEASE-RESISTANT PEPTIDES AS BBB SHUTTLES AND SHUTTLE-CARGO CONSTRUCTS
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机译：积极运输和抗蛋白酶抗性肽作为BBB梭和班车组建
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摘要
It is described a peptidic compound having in its structure a biradical of a peptide having 9-20 amino acids residues in length having at least a intrapeptide disulfide bond, a intrapeptide amide bond, an intrapeptide thioether bond, a Se-Se bond, an intrapeptide C-C bond, or an intrapeptide C=C bond; and comprising the amino acid sequence Xaa 1KAPETALXaa 2 (A)n1(A)n2(A)n3 (SEQ ID NO:1) Xaa 1 and Xaa 2 are an amino acid independently selected form C, D, E, K, O, Dap, Dab, Sec, Pen, AIGly, and alpha-Me-alpha-alkGly; n1, n2 and n3 are integers independently selected from 0 an 1, with the proviso that when at least one of n1, n2 and n3 is 0, then at least an intrapeptide bond is between Xaa 1 and Xaa 2.These peptidic compounds are useful as shuttles through the blood brain barrier (BBB). The constructs BBB-shuttle-cargo, being the cargo of a biologically active substance or for use in a diagnostic method, are useful in therapy and diagnosis.
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