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APPLICATION OF CAURENOXIDASE PISUM SATIVUM FOR HIGHLY EFFICIENT PRODUCTION OF REBAUDIOSIDES
APPLICATION OF CAURENOXIDASE PISUM SATIVUM FOR HIGHLY EFFICIENT PRODUCTION OF REBAUDIOSIDES
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机译：含氰氧化酶Pisum Sativum在高效生产Rebaudioside的应用
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摘要
Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a Pisum sativum kaurene oxidase or its variant kaurene oxidase. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.
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机译：本文提供了用于改善宿主细胞中甜醇糖苷的生产的组合物和方法。 在一些实施方案中，遗传细胞被遗传修饰，以包括编码Pisum Sativum Kaurene氧化酶或其变异kaurene氧化酶的异源核苷酸序列。 在一些实施方案中，宿主细胞还包含一种或多种异源核苷酸序列，所述异源核苷酸序列编码能够在宿主细胞中产生甜醇糖苷的途径的进一步酶。 本文所述的组合物和方法提供了甜菊糖糖苷的异源产生的有效途径，包括但不限于Rebaudioside D和Rebaudioside M.
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