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首页> 外国专利> METHODS OF DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A CENTRAL SEROUS CHORIORETINOPATHY

METHODS OF DETERMINING WHETHER A SUBJECT HAS OR IS AT RISK OF HAVING A CENTRAL SEROUS CHORIORETINOPATHY

机译：确定受试者是否具有或有患有中枢性浆液性胆体素病的危险的方法

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Central Serous chorioretinopathy (CSCR) is primarily an ocular disease, affecting the choroid and the retinal pigment epithelium. To date, no systemic biomarker of CSCR have been discovered that could link both forms and help the diagnosis in challenging cases. In the present invention, the inventors measure in European cohorts of CSCR patients (n=168) with (n=90) or without epitheliopathy (n=78) and a cohort of 153 control subjects without any ocular disease history, the serum levels of NGAL and the NGAL/MMP9 complex. Serum NGAL (ng/ml) was significantly higher in the control group (108.8±46.8) than in the CSCR cohort (80.4±46.4, p <0.0001). Serum NGAL (ng/ml) was significantly lower in the acute/ recurrent cohort (n=78, 71.3 ±32.1) than in the control and, than in the chronic cohort (n=90, 88.3±55, p=0.03). Similarly, Serum NGAL/MMP9 (ng/ml) levels was lower in the whole CSCR cohort (44.5±39.6) as compared to the controls (77.6±47.8, p<0.0001). Serum NGAL/MMP9 (ng/ml) were significantly lower in the acute/ recurrent cohort (37.6±37.9) than in the control and, than in the chronic cohort (50.5±40.3, p=0.002). Thus, in both forms of CSCR serum NGAL and NGAL/MMP9 are lower than in the control population, providing a biological link between the two forms and a potential susceptibility to oxidative stress and innate immune dysregulation. Systemic LCN2 being elevated in other retinal diseases, it represents a specific biomarker for CSCR.
机译：中央浆液性胆管胰病（CSCR）主要是一种眼部疾病，影响脉络膜和视网膜色素上皮。迄今为止，已发现CSCR的全身生物标志物可以链接两种形式并帮助诊断挑战性案件。在本发明中，本发明人在欧洲CSCR患者的欧洲群组中测量（n = 90）或没有上皮病（n = 78）和153个对照受试者的群组，没有任何眼部疾病史，血清水平NGAL和NGAL / MMP9复合物。对照组（108.8±46.8）中血清Ngal（Ng / ml）显着高于CSCR队列（80.4±46.4，P <0.0001）。急性/复发队列（n = 78,71.3±32.1）中血清Ngal（Ng / ml）显着低于对照，而不是慢性队列（n = 90,88.3±55，p = 0.03）。类似地，与对照相比，整个CSCR队列（44.5±39.6）中血清NGAL / MMP9（Ng / ml）水平较低（77.6±47.8，P <0.0001）。急性/复发队列（37.6±37.9）中血清NGAL / MMP9（Ng / mL）显着低于对照组，而不是在慢性队队（50.5±40.3，p = 0.002）中。因此，在两种形式的CSCR血清NGAL和NGAL / MMP9中低于对照群体，提供两种形式与对氧化应激和先天免疫剂量的潜在易感性之间的生物联系。系统性LCN2在其他视网膜疾病中升高，它代表了CSCR的特定生物标志物。

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