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Homogeneous nucleic acid bases with homogeneous hydrogen bonding interactions, Homo and heterobase pair biases and mismatch discrimination

机译：均相核酸碱具有均相氢键相互作用，同源和异代酶对偏置和失配鉴别

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摘要

In this specification γ－ Peptide nucleic acid γ As described in the case of PNA, a divalent nucleic acid base that binds to two nucleic acid chains of a match or mismatch is described when incorporated into a nucleic acid skeleton or nucleic acid analog skeleton.One or more divalent nucleic acid bases and γ A gene recognition reagent comprising a nucleic acid skeleton or nucleic acid analog skeleton such as PNA skeleton is also provided.The use of a gene recognition reagent containing divalent nucleic acid bases and monomers and divalent nucleic acid bases is also provided.Diagram

机译：在本说明书中，如PNA的情况下所描述的γ-肽核酸γ，当掺入核酸骨架或核酸类似骨架中时，描述了与匹配或不匹配的两个核酸链结合的二价核酸碱。还提供了包含含有核酸骨架或核酸类似骨架的诸如PNA骨架的基因识别试剂。使用含有二价核酸碱和单体和二价核酸碱的基因识别试剂。还提供了.diagram

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公开/公告号JP2021526805A

专利类型
公开/公告日2021-10-11

原文格式PDF
申请/专利权人カーネギーメロンユニバーシティ;
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申请/专利号JP20200567980
发明设计人ダニス、エイチ．エルワイ;シバジ、エイ．タトケ;アシフ、ワイ．シャイフ;ウェイ‐チェ、シェ;アリ、ナキ;ジェイ．ディニチ、ペレラ;
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申请日2019-06-07
分类号C12N15/11;C12N15/10;C12Q1/6813;C12Q1/6837;C12Q1/6876;C12M1;A61P43;C07D213/64;C07D239/36;C07D473/32;C07D473/30;A61K31/4412;A61K31/513;A61K31/52;A61K31/522;G01N33/50;
国家 JP
入库时间 2022-08-24 21:35:08

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