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Intrinsic Microfluidic CE-MS Analysis of Antibody Charge Heterogeneity
Intrinsic Microfluidic CE-MS Analysis of Antibody Charge Heterogeneity
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机译：固有的微流体CE-MS分析抗体电荷异质性
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摘要
A method for detecting and/or distinguishing post-translational modified variants of an antibody of interest in a sample. The method comprises the steps of: contacting a sample comprising one or more antibodies of interest with a protease to digest the sample into antibody fragments; separating antibody fragments by molecular weight and/or charge in one or more capillaries using capillary electrophoresis; eluting the isolated antibody fragment from the one or more capillaries; and determining the mass of the eluted antibody fragment by mass spectral analysis to detect and/or distinguish post-translational modified variants of the antibody of interest.
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