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METHOD FOR DIFFERENTIAL DIAGNOSIS OF NODULAR FORMATIONS OF THE HUMAN THYROID GLAND
METHOD FOR DIFFERENTIAL DIAGNOSIS OF NODULAR FORMATIONS OF THE HUMAN THYROID GLAND
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机译：鉴别诊断人甲状腺结节腺体的鉴别诊断
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摘要
FIELD: medicine. ;SUBSTANCE: invention relates to the field of medicine, in particular to oncology, and is intended for the differential diagnosis of nodular formations of the human thyroid gland. A sample of the thyroid nodular formation tissue is taken, the total RNA pool is isolated from the sample, the expression level of the HMGA2 gene, mitochondrial DNA is analyzed, and the V600E mutation in the BRAF gene is determined. The expression level of microRNA-146b, -221, -375 is measured. Additionally, the expression level of the GCM2 gene is measured. The conclusion about the presence and nature of nodular formation is made on the basis of the decision tree, according to which the analyzed sample is attributed to one of the selected from the following group: parathyroid nodular formation, benign thyroid nodular formation, malignant thyroid nodular formation, including papillary cancer, medullary cancer, Hurthle cell cancer, follicular tumors with malignancy markers. ;EFFECT: invention provides an increase in the accuracy of the method for differential diagnosis of nodular formations of the thyroid gland and the expansion of its functional capabilities. ;1 cl, 1 dwg, 16 tbl, 8 ex
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机译：领域：医学。 ;物质：发明涉及医学领域，特别是肿瘤学，旨在鉴于人甲状腺的结节性诊断。取出甲状腺结节形成组织的样品，从样品中分离总RNA池，分析了HMGA2基因的表达水平，线粒体DNA，并测定了BRAF基因中的V600E突变。测量microRNA-146b，-221，-375的表达水平。另外，测量GCM2基因的表达水平。关于结节形成的存在和性质的结论是在决策树的基础上进行的，分析的样品归因于来自以下组中的选定中的一种：甲状旁腺结节性，良性甲状腺结节形成，恶性甲状腺结节形成，包括乳头状癌，髓质癌，呼吸细胞癌，恶性肿瘤卵泡肿瘤。 ;效果：发明提高了甲状腺结节性诊断的方法的准确性，以及其功能能力的扩展。 ; 1 cl，1 dwg，16 tbl，8 ex
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