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NOVEL MRNA BASED PROGNOSTIC INDEX DERIVED FROM DIFFERENTIAL EXPRESSION ANALYSIS IMPROVES OVERALL SURVIVAL ESTIMATES IN GLIOBLASTOMA
NOVEL MRNA BASED PROGNOSTIC INDEX DERIVED FROM DIFFERENTIAL EXPRESSION ANALYSIS IMPROVES OVERALL SURVIVAL ESTIMATES IN GLIOBLASTOMA
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机译：衍生自鉴别表达分析的新型mRNA的预后指数可提高胶质母细胞瘤的总体存活估计
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摘要
The present invention relates to diagnostic assays useful in classification of patients for selection of cancer therapy, and relates to a method of using a select family member of the Wnt signaling pathway (WIF1), an important component of the insulin-like growth factor pathway (IGFBP3), and other signaling factors (e.g., NGFR, IBSP, and HISTLH3G and COL1A2) as prognostic markers and potential therapeutic targets for patients with Glioblastoma Multiforme (GBM). In particular, the present invention is a novel GBM Prognostic Index (GPI) that predicts overall survival (OS) in GBM patients treated with the current standard of care.
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