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COMPOSITIONS AND METHODS FOR THE PREVENTION OF STRESS-INDUCED FEAR, DEPRESSIVE-LIKE AND ANXIETY- LIKE BEHAVIOR
COMPOSITIONS AND METHODS FOR THE PREVENTION OF STRESS-INDUCED FEAR, DEPRESSIVE-LIKE AND ANXIETY- LIKE BEHAVIOR
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机译：预防应激诱导的恐惧，抑郁和焦虑和焦虑的组合物和方法
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摘要
The present disclosure relates to methods and compositions which prevent and protect against all three types of stress-induced maladaptive behaviors-fear, depressive-like, and anxiety-like behavior, which in turn can prevent a wide variety of stress-induced fear, anxiety, and depressive disorders. In some aspects, the compositions and methods use a serotonin 4 receptor (5 -hydroxy tryptamine (serotonin) receptor 4, or 5-HT4R) agonist in combination with: ketamine, a ketamine analog, or a pharmaceutically acceptable salt, derivative, or metabolite thereof; an antagonist of the glutamate N -methyl-D- aspartate (NMD A) receptor (NMDAR); or an agonist of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR). In certain aspects, the present composition or compositions can be administered prior to a stressor. In certain aspects, the present composition or compositions can be administered after a stressor.
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