首页>
外国专利>
Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
展开▼
机译:结合T细胞的多官能分子及其用途,以治疗自身免疫病症
展开▼
页面导航
摘要
著录项
相似文献
摘要
Multifunctional molecules that include i) an antigen binding domain that binds to a TCR variable beta chain (TCRBV) antigen; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; and/or (iv) a death receptor signal enhancer. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating autoimmune diseases using the aforesaid molecules.
展开▼