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NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS

机译:制备可溶性胍酸盐环酶刺激器的新方法

摘要

The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.;
机译:本公开涉及制备可用作可溶性胍基环化酶(SGC)的刺激剂的化合物的新方法。 这些方法适用于大规模制备,并产生稳定的3-(2-嘧啶基)式(I)的吡唑,包括化合物(I),高纯度和产率。 本发明具有容易反应条件的额外优点,可缩放大规模制造。 本公开还提供了用于制备所述化合物的新型中间体。

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