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TARGETED RADIOPHARMACEUTICALS FOR TUMORS, AND COMBINATION THERAPY OF TARGETED RADIOTHERAPY THEREOF AND IMMUNOTHERAPY UNDER GUIDANCE OF IMAGES
TARGETED RADIOPHARMACEUTICALS FOR TUMORS, AND COMBINATION THERAPY OF TARGETED RADIOTHERAPY THEREOF AND IMMUNOTHERAPY UNDER GUIDANCE OF IMAGES
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机译：针对肿瘤的针对性放射性药物，以及在图像指导下的靶向放射治疗和免疫疗法的联合治疗
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摘要
Disclosed are a structurally modified RGD polypeptide, a complex consisted of the polypeptide and a radionuclide and a pharmacological composition comprising the complex, the said pharmacological composition being useful for diagnosis or treatment of the integrin αvβ3-positive tumors. Also disclosed is a preferred pharmacological composition which further comprise an immunotherapeutic medicament and an optional nanoantibody molecular imaging probe. Treatment with a PD-L1 blockade after the targeted radioactive therapy in the present invention can archive the optimal synergic efficacy. Moreover, with administration of PD-1 or PD-L1 nanoantibody molecular imaging probe of the invention, expression of PD-1 or PD-L1 in the tumor after targeted radiotherapy can be observed, which has guiding significance in establishing therapeutic strategy for the combination therapy of targeted radiotherapy and immunotherapy and helps to increase the effect of the combination therapy.
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