首页> 外国专利> PROMOTORS FOR EPIDERMAL KERATINOCYTE GROWTH, FOR FILAGGRIN MRNA EXPRESSION, FOR SERINE PALMITOYLTRANSFERASE MRNA EXPRESSION, FOR INVOLUCRIN EXPRESSION AND FOR ATP PRODUCTION

PROMOTORS FOR EPIDERMAL KERATINOCYTE GROWTH, FOR FILAGGRIN MRNA EXPRESSION, FOR SERINE PALMITOYLTRANSFERASE MRNA EXPRESSION, FOR INVOLUCRIN EXPRESSION AND FOR ATP PRODUCTION

机译：表皮角膜炎细胞生长的推广剂，用于丝毫棕榈酰丙胺的乳头棕榈酰丙胺酶mRNA表达，用于调用表达和用于ATP生产

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摘要

PROBLEM TO BE SOLVED: To provide agents for promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production by finding substances having excellent activity in promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production.;SOLUTION: An epidermal keratinocyte growth promoting agent of the invention comprises one or more effective ingredients selected from the group consisting of 2-ketoglutaric acid, 2-isopropyl malate, inosine 5'-monophosphoric acid, succinic acid, malic acid and pyruvic acid. Also, a filaggrin mRNA expression promotor, a serine palmitoyltransferase mRNA expression promotor, an involucrin expression promotor of the invention comprise, as an effective ingredient, 2-ketoglutaric acid. Further an ATP production promotor of the invention comprises 2-isopropyl malate as an effective ingredient.;SELECTED DRAWING: None;COPYRIGHT: (C)2021,JPO&INPIT

机译：要解决的问题：通过在促进表皮角蛋白细胞生长，Filaggrin mRNA表达，丝氨酸棕榈酰转移酶mRNA表达，丝氨酸棕榈酰转移酶mRNA表达，其中包含优异活性的物质，提供用于促进表皮角蛋白细胞生长，Filagrin mRNA表达，丝氨酸棕榈酰表达，丝氨酸棕榈酰基表达，丝氨酸棕榈酰基表达，丝氨酸棕榈酰基表达，丝氨酸棕榈酰基表达，丝氨酸的表达或ATP生产，所述物质表达或ATP生产。;溶液：本发明的表皮角蛋白细胞生长促进剂包括选自2-酮戊酸，2-异丙酸丙酸2-丙酸盐，杀虫剂5'-单磷酸，琥珀酸，苹果酸的一种或多种有效成分。酸和丙酮酸。此外，本发明的一种丝虫素mRNA表达促进剂，丝氨酸棕榈酰丙酰酶mRNA表达促进剂，其作为有效成分，2-酮戊酸。此外，本发明的ATP生产促进剂包含2-异丙基作为有效成分。;选定的绘图：无;版权：（c）2021，JPO和INPIT

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公开/公告号JP2021127344A

专利类型
公开/公告日2021-09-02

原文格式PDF
申请/专利权人 MARUZEN PHARMACEUT CO LTD;
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申请/专利号JP20210021884
发明设计人 MINAMIDA MIKA;KAWAKAMI HIDEAKI;IWATAKE MIWA;KUWABARA HIROMOTO;KONISHI MASATOSHI;OKUDA HIROSHI;OTO NOBUAKI;
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申请日2021-02-15
分类号A61K31/19;A61K31/194;A61K31/708;A61P43;A61P17/16;A61K8/365;A61K8/362;A61K8/60;A61Q19/08;
国家 JP
入库时间 2022-08-24 22:24:43

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