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ULTRASENSITIVE BIOSENSOR USING BENT AND CURVED FIELD EFFECT TRANSISTOR BY DEBYE LENGTH MODULATION

机译：通过德义长度调制使用弯曲和弯曲场效应晶体管的超敏感生物传感器

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摘要

Provided are biosensors, systems and related methods of using the biosensors and systems. The biosensor comprises a field-effect transistor (FET) having a crumpled geometry to effectively increase the detection sensitivity of a target molecule in an ionic solution. A FET having a crumpled semiconductor material channel can form a π-π interaction with single stranded DNA (ssDNA) for amplification detection applications. Increasing amount of ssDNA in an amplification reaction solution is incorporated into an amplified double stranded DNA, with increasing amplification, resulting in a lower amount of ssDNA primers. The FET is contacted with the amplified solution to electrically detect an amount of ssDNA primer in the amplified solution, thereby detecting amplification based on a decreased amount of ssDNA bound to the FET. Also provided are biosensors that can detect biomolecules more generally, such as protein, polypeptides, polynucleotides, or small molecules.

机译：提供了使用生物传感器和系统的生物传感器，系统和相关方法。生物传感器包括场效应晶体管（FET），其具有皱折的几何形状，以有效地提高离子溶液中靶分子的检测灵敏度。具有弄皱的半导体材料通道的FET可以形成与单链DNA（SSDNA）的π-π相互作用以进行扩增检测应用。将扩增反应溶液中的SSDNA的增加量掺入扩增的双链DNA中，随着扩增的增加，导致较少量的SSDNA引物。 FET与扩增的溶液接触以在扩增的溶液中电检测SSDNA引物的量，从而基于与FET结合的降低的SSDNA量检测扩增。还提供了能够更普遍地检测生物分子的生物传感器，例如蛋白质，多肽，多核苷酸或小分子。

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公开/公告号WO2021174068A1

专利类型
公开/公告日2021-09-02

原文格式PDF
申请/专利权人 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;
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申请/专利号WO2021US20006
发明设计人 HWANG MICHAEL;BASHIR RASHID;HEIRANIAN MOHAMMAD;NAM SUNGWOO;ALURU NARAYAN;VAN DER ZANDE AREND;MURPHY CATHERINE J.;CHOI JONGHYUN;KIM YERIM;
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申请日2021-02-26
分类号H01L27/085;C12Q1/6874;G01N27/414;H01L29/786;
国家 US
入库时间 2022-08-24 22:25:16

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