首页> 外国专利> ANALYSIS OF HLA ALLELIES IN TUMORS AND ITS APPLICATION

ANALYSIS OF HLA ALLELIES IN TUMORS AND ITS APPLICATION

机译:肿瘤中HLA等位基因分析及其应用

摘要

The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
机译:本发明涉及用于确定HLA等位基因是否在受试者中肿瘤中丢失的方法,其中所述方法包括确定所述肿瘤中所述HLA等位基因的特定拷贝数的步骤。 本发明还涉及一种用于治疗受试者中癌症的方法,包括靶向靶向的新抗原,所述新宿生预测由HLA等位基因编码的HLA分子呈现,所述HLA等位基因已经确定不被丢失在所述受试者中的肿瘤中。

著录项

  • 公开/公告号RU2020106732A3

    专利类型

  • 公开/公告日2021-11-01

    原文格式PDF

  • 申请/专利权人

    申请/专利号RU20200106732

  • 发明设计人

    申请日1900-01-01

  • 分类号G01N33/50;

  • 国家 RU

  • 入库时间 2022-08-24 22:26:42

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