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METHOD FOR VISUAL SEMI-QUANTITATIVE EVALUATION OF CDX-2 PROTEIN EXPRESSION IN TISSUES BY IMMUNOHISTOCHEMICAL METHOD

机译：免疫组织化学方法对组织中CDX-2蛋白表达的视觉半定量评价的方法

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FIELD: medicine. ;SUBSTANCE: invention relates to the field of medicine, namely to immunohistochemical research methods. To evaluate the expression of CDX-2 protein in tissues, the expression index is calculated by summing the expression pattern and the product of the length of the label by the intensity of the label. The expression pattern is evaluated by the location of positively colored cells. The length of the label is estimated, reflecting the percentage of CDX-2-positive cells in the studied volume of the material. The intensity of the label reflecting the staining of the nucleus is evaluated. ;EFFECT: method makes it possible to obtain an integral indicator of CDX-2 expression, to rank the intensity of changes in tissue, to take into account cases with uneven CDX-2 expression within the studied volume of material, regardless of the orientation of the biopsy material. ;1 cl, 2 dwg, 2 ex

机译：领域：医学。 ;物质：发明涉及医学领域，即免疫组化研究方法。为了评估组织中CDX-2蛋白的表达，通过将表达模式和标签长度的表达式和产物通过标签的强度来计算表达指数。表达模式由阳性细胞的位置评估。估计标签的长度，反映了所研究的材料体积中CDX-2阳性细胞的百分比。评估反映核的染色的标签的强度。 ;效果：方法使得可以获得CDX-2表达的积分指示，以对组织的变化强度进行排序，以考虑在研究的材料体积内具有不均匀CDX-2表达的案例，无论方向活检材料。 ; 1 cl，2 dwg，2前

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公开/公告号RU2758888C1

专利类型
公开/公告日2021-11-02

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE BIUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIIA «OMSKII GOSUDARSTVENNYI MEDITSINSKII UNIVERSITET» MINISTERSTVA ZDRAVOOKHRANENIIA ROSSIISKOI FEDERATSII (FGBOU VO OMGMU MINZDRAVA ROSSII);
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申请/专利号RU20200143364
发明设计人 PARYGINA MARIIA NIKOLAEVNA (RU);KONONOV ALEKSEI VLADIMIROVICH (RU);MOZGOVOI SERGEI IGOREVICH (RU);SHIMANSKAIA ANNA GENNADEVNA (RU);OSTROGLIADOVA IRINA ALEKSEEVNA (RU);
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申请日2020-12-28
分类号G01N33/53;G01N1/30;
国家 RU
入库时间 2022-08-24 22:26:57

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