首页> 外国专利> miRNA-214-3p miRNA-1290-3pmiRNA-214-3p and miRNA-1290-3p as biomarker for predicting or diagnosing pre-eclampsia

miRNA-214-3p miRNA-1290-3pmiRNA-214-3p and miRNA-1290-3p as biomarker for predicting or diagnosing pre-eclampsia

机译:miRNA-214-3P miRNA-1290-3PMIRNA-214-3P和MiRNA-1290-3P作为预测或诊断预先印痫前的生物标志物

摘要

The present invention relates to miRNA-214-3p and miRNA-1290-3p as biomarkers for prediction or diagnosis of preeclampsia, specifically, at least one selected from miR-214-3p and miR-1290-3p in a sample of a subject A method for predicting or diagnosing preeclampsia, comprising measuring the concentration of microRNA, a composition for predicting or diagnosing preeclampsia comprising a means for measuring the concentration of miR-214-3p or miR-1290-3p, and It relates to a kit for predicting or diagnosing preeclampsia comprising this composition. The preeclampsia biomarkers provided through the present invention, that is, miRNA-214-3p and miRNA-1290-3p, have very excellent sensitivity and specificity, and can be safely and easily applied because they can be measured in blood or serum. It also has the advantage of being able to increase reliability when used in combination because it has a correlation with the biomarker of Therefore, by using the information providing method, composition or kit of the present invention, it is possible to very effectively predict or diagnose preeclampsia of women, especially Korean women.
机译:本发明涉及MiRNA-214-3P和MiRNA-1290-3P作为生物标志物,用于预测或诊断预胰抗,特别是在受试者样本中选自miR-214-3p和miR-1290-3p的至少一种。预测或诊断预胰抗的方法,包括测量microRNA的浓度,一种用于预测或诊断预胰抗的组合物,其包含用于测量miR-214-3p或miR-1290-3p的浓度,并且涉及用于预测或用于预测或预测的套件诊断包含该组合物的预胰抗。通过本发明提供的前普兰碱生物标志物,即miRNA-214-3p和miRNA-1290-3p具有非常优异的敏感性和特异性,并且可以安全且容易地施加,因为它们可以在血液或血清中测量。它还具有能够在组合使用时能够提高可靠性的优点,因为它具有与生物标志物的相关性,因此通过使用本发明的信息提供方法,组合物或试剂盒,可以非常有效地预测或诊断妇女的普雷斯普拉姆,尤其是韩国女性。

著录项

  • 公开/公告号KR102326813B1

    专利类型

  • 公开/公告日2021-11-16

    原文格式PDF

  • 申请/专利权人 강원대학교산학협력단;

    申请/专利号KR20200047578

  • 发明设计人 김영명;김수지;박민식;

    申请日2020-04-20

  • 分类号C12Q1/6883;

  • 国家 KR

  • 入库时间 2022-08-24 22:30:02

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