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Daxx Diagnosis of chronic liver disease by measuring Daxx protein in serum
Daxx Diagnosis of chronic liver disease by measuring Daxx protein in serum
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机译:血清中Daxx蛋白慢性肝病的Daxx诊断
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摘要
The present invention relates to a biomarker for diagnosing chronic liver disease Daxx and its use, and more particularly, to a composition for diagnosing chronic liver disease comprising an agent capable of measuring the mRNA of Daxx (Death Domain Associated Protein) gene or its protein expression level , to a method for diagnosing chronic liver disease and a kit for diagnosing chronic liver disease using the same. In the present invention, as a result of analyzing the serum of patients with chronic liver disease, it was confirmed that the expression of Daxx was increased. In addition, in chronic liver disease, the blood concentration of Daxx in chronic liver disease was determined by the APRI calculated using the AST and ALT, which reflect liver damage, the platelet count, which reflects the progress of liver fibrosis, and the AST concentration and platelet ratio. As it was confirmed that there is a tendency to increase with age, it was confirmed that Daxx can be applied as a biomarker for diagnosing chronic liver disease.
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