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Daxx Diagnosis of chronic liver disease by measuring Daxx protein in serum

机译:血清中Daxx蛋白慢性肝病的Daxx诊断

摘要

The present invention relates to a biomarker for diagnosing chronic liver disease Daxx and its use, and more particularly, to a composition for diagnosing chronic liver disease comprising an agent capable of measuring the mRNA of Daxx (Death Domain Associated Protein) gene or its protein expression level , to a method for diagnosing chronic liver disease and a kit for diagnosing chronic liver disease using the same. In the present invention, as a result of analyzing the serum of patients with chronic liver disease, it was confirmed that the expression of Daxx was increased. In addition, in chronic liver disease, the blood concentration of Daxx in chronic liver disease was determined by the APRI calculated using the AST and ALT, which reflect liver damage, the platelet count, which reflects the progress of liver fibrosis, and the AST concentration and platelet ratio. As it was confirmed that there is a tendency to increase with age, it was confirmed that Daxx can be applied as a biomarker for diagnosing chronic liver disease.
机译:本发明涉及一种用于诊断慢性肝病Daxx及其使用的生物标志物,更具体地,涉及用于诊断慢性肝病的组合物,所述组合物包含能够测量Daxx(死亡结构域相关蛋白质)基因或其蛋白质表达的mRNA的药剂水平,以诊断慢性肝病的方法和用于使用该诊断诊断慢性肝病的试剂盒。在本发明中,由于分析慢性肝病患者血清的结果,证实Daxx的表达增加。此外,在慢性肝病中,慢性肝病中Daxx的血液浓度由使用AST和ALT计算的APRI计算,反映肝纤维化的血小板计数和AST浓度和血小板比。由于证实随着年龄的增长趋于增加,证实Daxx可以作为诊断慢性肝病的生物标志物。

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