首页> 外国专利> THE APPLICATION OF URSODEOXYCHOLIC ACID OR ITS PHARMACEUTICAL SALT IN THE PREPARATION OF AN ANTITUMOR DRUG AND AN ANTITUMOR DRUG

THE APPLICATION OF URSODEOXYCHOLIC ACID OR ITS PHARMACEUTICAL SALT IN THE PREPARATION OF AN ANTITUMOR DRUG AND AN ANTITUMOR DRUG

机译:铜氧胆酸或其药物盐在抗肿瘤药物和抗肿瘤药物制备中的应用

摘要

The present invention discloses the application of an ursodeoxycholic acid and its pharmaceutical salt in the preparation of an antitumor drug and an antitumor drug. Through research, it is discovered that ursodeoxycholic acid and its pharmaceutical salt have good inhibition effect on a variety of tumor cells, and further research reveals that they function by reducing the proportion of regulatory T cells in tumor infiltrating lymphocytes. Therefore, ursodeoxycholic acid can be used in the preparation of an antitumor drug. Besides, as a clinically used choleretic drug, ursodeoxycholic acid does not require clinical safety evaluation, and has good application prospects. It can also be used as an ancillary drug to improve the therapeutic effect of anti-PD-1 drugs.
机译:本发明公开了铜氧胆酸及其药物盐在抗肿瘤药物和抗肿瘤药物制备中的应用。 通过研究,发现核致氧胆酸及其药盐对各种肿瘤细胞具有良好的抑制作用,进一步的研究表明,通过降低肿瘤浸润淋巴细胞中调节性T细胞的比例来起作用。 因此,核致氧胆酸可用于制备抗肿瘤药物。 此外,作为临床使用的胆汁药物,熊科酸胆酸不需要临床安全评估,并具有良好的应用前景。 它也可用作辅助药物以改善抗PD-1药物的治疗效果。

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