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Therapeutic agent for intervertebral disc degeneration and intervertebral disc cell culture material

机译：椎间盘变性和椎间盘细胞培养物的治疗剂

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摘要

A method of regenerating the nucleus pulposus when treating disc degeneration has been proposed. Although collagen or atelocollagen can maintain the intervertebral distance to some extent, there is no regeneration of nucleus pulposus cells. On the other hand, transplanting live cells or nucleus pulposus cells from donors is not safe. The therapeutic agent for intervertebral disc degeneration containing LASCol in which the end of collagen according to the present invention is enzymatically cleaved can be administered to the nucleus pulposus region where the nucleus pulposus has been lost to maintain the intervertebral distance and the nucleus pulposus cells and / or It can promote the regeneration of annulus fibrosus cells.

机译：提出了一种在处理椎间盘退化时再生核浆水的方法。虽然胶原蛋白或Atelocollagen可以在一定程度上保持椎间距离，但没有细胞核牙髓细胞的再生。另一方面，移植活细胞或来自供体的细胞核浆鱼细胞不安全。含有溶羊板的椎间盘变性的治疗剂，其中酶促切割的胶原蛋白的末端可以施用于核脉搏区，其中核浆气已丢失以维持椎间距离和核脉搏细胞和/ 或者它可以促进环状纤维细胞的再生。

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公开/公告号JP6984829B2

专利类型
公开/公告日2021-12-22

原文格式PDF
申请/专利权人国立大学法人神戸大学;学校法人近畿大学;公益財団法人神戸医療産業都市推進機構;
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申请/专利号JP20190569584
发明设计人由留部崇;武岡由樹;森本康一;國井沙織;尾前薫;
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申请日2019-01-31
分类号A61L27/24;A61K38/39;A61P19/08;A61P43;A61L27/26;A61L27/18;A61L27/20;A61L27/58;A61L27/48;A61L27/52;C12P21/02;C12N5/077;A61K47/10;A61K47/36;A61K47/42;
国家 JP
入库时间 2022-08-24 22:57:06

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