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RNA induced targeting of genomic and epigenome regulatory proteins to specific genomic loci
RNA induced targeting of genomic and epigenome regulatory proteins to specific genomic loci
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机译:RNA诱导基因组和表观蛋白酶体调节蛋白的靶向特异性基因组基因素
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摘要
Problem to be solved: to provide a method and structure for targeting heterologous functional domains such as transcription activation factors to specific genomic loci by RNA induction.A method for silencing or suppressing the expression of a target gene in a cellThe method comprises (I) catalytically inactive CRISPR related 9 (dcas9) proteins linked to a heterofunctional domainFusion proteinWhereThe heterogeneous functional domainIs a transcriptional silencer or transcriptional repression domainFusion protein(II) the step of expressing one or more guide RNAs to the target gene;Method.Selection diagram
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