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CARBON NANOTUBE COMPOSITE VECTOR HAVING SYNERGISTIC EFFECT OF PHOTOTHERMAL THERAPY AND GENE THERAPY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
CARBON NANOTUBE COMPOSITE VECTOR HAVING SYNERGISTIC EFFECT OF PHOTOTHERMAL THERAPY AND GENE THERAPY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
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机译：具有光热疗和基因治疗的协同作用的碳纳米管复合载体，其制备方法及其应用
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摘要
A carbon nanotube composite vector having a synergistic effect of photothermal therapy and gene therapy, a preparation method therefor, and an application thereof. The vector includes a vector moiety and a gene, and the vector moiety includes carbon nanotubes, a peptide lipid, and/or an additive. A modifier is immobilized on the carbon nanotubes by a self-assembly process to prepare the composite vector that can carry and transfer the gene. The composite vector overcomes the problems that pure carbon nanotubes have poor water solubility, low biocompatibility, and poor gene carrying and transfer efficiency; moreover, the composite vector has higher photothermal conversion performances and gene transfer efficiency, reduces cytotoxicity of carbon nanotubes, and alleviates the problem of localized accumulation of carbon nanotubes. The synergistic effect of photothermal therapy and gene therapy is applied to resolve the problem in tumor treatment that the efficacy of a single treatment method is poor.
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