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METHODS AND COMPOSITIONS FOR THE TREATMENT OF COVID-19 AND ASSOCIATED RESPIRATORY DISTRESS AND MULTI-ORGAN FAILURE, SEPSIS, ACUTE RESPIRATORY DISTRESS SYNDROME, AND CORDIOVASCULAR DISEASES
METHODS AND COMPOSITIONS FOR THE TREATMENT OF COVID-19 AND ASSOCIATED RESPIRATORY DISTRESS AND MULTI-ORGAN FAILURE, SEPSIS, ACUTE RESPIRATORY DISTRESS SYNDROME, AND CORDIOVASCULAR DISEASES
Disclosed herein are methods and compositions for treatment of COVID-19 and associated sepsis, respiratory distress and organ failure, acute respiratory distress syndrome, sepsis, infection-induced organ failure, restenosis, critical limb ischemia, and vascular diseases associated with impaired endothelial regeneration, vascular repair, and vascular regeneration. In some embodiments, the methods include administering an effective amount of one or more of a) Dexamethasone, Resveratrol, N-acetylcysteine, Apocynin, Ebselen, APX-115, NOX2 inhibiting peptide, NOX2 inhibiting nucleic acid, Thienopyridine, or b) Selisistat, AG-1031, rabeprazole, phenazopyridine, roxadustat, molidustat, vadadustat, desidustat, decitabine, azacytidine, and analogues thereof, FOXMl expressing nucleic acid, HIF1A expressing nucleic acid, SIRT1 inhibiting nucleic acid, EGLN1 inhibiting nucleic acid, or c) combination of one of a with one of b to a subject in need thereof. In some embodiments, the monotherapy or combination therapy is particularly useful for treatment of an elderly subject, and is useful to treat a subject at any age.
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