The present invention provides methods and compositions for treating epithelioid cell tumors (eg, PEComa) by administering a composition comprising nanoparticles comprising an mTOR inhibitor and albumin. In some embodiments, a method of treating PEComa in an individual in need thereof is provided comprising administering to the individual an effective amount of a composition comprising nanoparticles comprising a rims drug and albumin. In some embodiments, the rimus drug is sirolimus. In some embodiments, the albumin is human albumin (eg, human serum albumin). In some embodiments, these nanoparticles comprise sirolimus associated with albumin (eg, coated with albumin).
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