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PERIPHERAL BLOOD TCR MARKER SEQUENCE FOR COLORECTAL CANCER, DETECTION KIT THEREFOR AND APPLICATION THEREOF
PERIPHERAL BLOOD TCR MARKER SEQUENCE FOR COLORECTAL CANCER, DETECTION KIT THEREFOR AND APPLICATION THEREOF
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机译：结直肠癌的外周血TCR标记序列，其检测试剂盒及其应用
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摘要
Disclosed are a peripheral blood TCR marker for colorectal cancer, a detection kit therefor and an application thereof. The marker comprises at least one of the proteins set forth in the sequence SpecSeq1-100. In the present invention, on the basis of a high-throughput sequencing method, only a small amount of peripheral blood needs to be taken. RNA is extracted, and an immune profile library is established by means of processing samples. Next, a characteristic TCR sequence in the peripheral blood of colorectal cancer is first determined by means of high-throughput sequencing and TCR data analysis, and then test results of a sample to be tested are compared to the characteristic TCR sequence so as to determine whether a patient has colorectal cancer. In the present invention, a huge number of colorectal cancer-specific TCR sequences may be compared at the same time, which has higher specificity and accuracy than detecting one or several markers separately, thereby increasing the diagnosis efficiency.
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