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6,5-fused heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor

机译：6,5-稠合的杂芳基哌啶醚醚醚构型调节剂M4毒蕈碱乙酰胆碱受体

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摘要

The present invention is directed to 6,5-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

机译：本发明涉及6,5-稠合的杂芳基醚化合物，其是M4毒蕈碱乙酰胆碱受体的变构调节剂。本发明还涉及本文所述的化合物在潜在的治疗或预防神经和精神病疾病和疾病中使用，其中涉及M4毒蕈碱乙酰胆碱受体的疾病。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在的预防或治疗涉及M4毒蕈碱乙酰胆碱受体的潜在预防或治疗中的用途。

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公开/公告号US11230556B2

专利类型
公开/公告日2022-01-25

原文格式PDF
申请/专利权人 MERCK SHARP & DOHME CORP.;
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申请/专利号US201716471672
发明设计人 XIAOLEI GAO;SANDRA L. KNOWLES;CHUNSING LI;MICHAEL MAN-CHU LO;ROBERT D. MAZZOLA JR.;DEBRA L. ONDEYKA;
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申请日2017-12-18
分类号C07D498/04;C07D471/04;C07D487/04;C07D491/048;C07D513/04;C07D471/14;C07D498/14;C07D401/14;
国家 US
入库时间 2022-08-24 23:31:07

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