首页> 外国专利> COMBINATION OF MORPHINAN COMPOUNDS AND ANTIDEPRESSANT FOR THE TREATMENT OF PSEUDOBULBAR AFFECT, NEUROLOGICAL DISEASES, INTRACTABLE AND CHRONIC PAIN AND BRAIN INJURY

COMBINATION OF MORPHINAN COMPOUNDS AND ANTIDEPRESSANT FOR THE TREATMENT OF PSEUDOBULBAR AFFECT, NEUROLOGICAL DISEASES, INTRACTABLE AND CHRONIC PAIN AND BRAIN INJURY

机译：吗啡南化合物和抗抑郁药的组合治疗伪波筋的影响，神经疾病，棘爪和慢性疼痛和脑损伤

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摘要

Provided herein are compositions comprising a dextromethorphan analog according to Formula I or Formula II or a pharmaceutically acceptable salt thereof of either of the foregoing, and a co-agent, e.g., an antidepressant such as a serotonin norepinephrine reuptake inhibitor; a serotonin noradrenaline dopamine reuptake inhibitor; a norepinephrine dopamine reuptake inhibitor; a monoamine oxidase inhibitor; a selective serotonin reuptake inhibitor; and a tricyclic antidepressant or a pharmaceutically acceptable salt of any of the foregoing. The compositions are useful in the treatment of pseudobulbar affect, neuropathic pain, neurodegenerative diseases, brain injuries, and the like.

机译：本文提供了包含根据式I或式II的葡聚糖类似物的组合物或前述任一种的药学上可接受的盐，以及辅助剂，例如抗抑郁药，例如血清蛋白脑卟啉再摄取抑制剂; 血清素诺肾上腺素多巴胺再摄取抑制剂; 脑肾上腺素多巴胺再生抑制剂; 单胺氧化酶抑制剂; 一种选择性血清素再摄取抑制剂; 和任何前述内容的三环抗抑郁药或药学上可接受的盐。该组合物可用于治疗伪麻醉，神经性疼痛，神经变性疾病，脑损伤等。

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公开/公告号US2022023292A1

专利类型
公开/公告日2022-01-27

原文格式PDF
申请/专利权人 CONCERT PHARMACEUTICALS INC.;
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申请/专利号US202117181976
发明设计人 AMANDA THOMAS;
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申请日2021-02-22
分类号A61K31/485;A61K31/135;A61K31/138;A61K31/343;A61K31/4525;A61K45/06;A61K31/15;A61K31/137;
国家 US
入库时间 2022-08-24 23:33:58

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