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METHOD FOR IDENTIFYING DISEASE PHENOTYPE BASED ON COMBINED SCORE OF SIGNIFICANT GENE EXPRESSION SIGNATURES FROM TRANSCRIPTOME SAMPLE OF PATIENTS
METHOD FOR IDENTIFYING DISEASE PHENOTYPE BASED ON COMBINED SCORE OF SIGNIFICANT GENE EXPRESSION SIGNATURES FROM TRANSCRIPTOME SAMPLE OF PATIENTS
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机译：基于转录患者转录组样本的显着基因表达鉴定的组合评分鉴定疾病表型的方法
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摘要
The disease phenotype determination method is a method for determining a disease in a computing device operated by at least one processor. Gene expression data of a patient's peripheral blood mononuclear cells (PBMC) from a microarray database and Collecting gene expression data of peripheral blood mononuclear cells, evaluating the similarity between the collected gene expression data to select genes showing a significant difference in expression between the gene expression data of a patient and the gene expression data of a normal person; Checking the overexpressed and repressed genes for the disease state versus the normal state among the selected genes, based on the expression values of the overexpressed genes and the expression values of the repressed genes, determining a reference disease prediction gene score; And if the disease prediction gene score calculated based on the gene expression value in the input random sample is higher than the reference disease prediction gene score, determining the random sample as a disease sample.
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