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MEDICINAL SOLID PREPARATION OF TOLVAPTAN AND PREPARATION METHOD THEREFOR
MEDICINAL SOLID PREPARATION OF TOLVAPTAN AND PREPARATION METHOD THEREFOR
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机译:托伐普坦的药用固体制剂及其制备方法
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摘要
A medicinal solid preparation containing tolvaptan and a preparation method therefor. The preparation method comprises converting active pharmaceutical ingredients of tolvaptan into amorphous forms by spray-drying, which is characterized by controlling the amorphous solid dispersion powder to be 35-80 microns in particle size D90; and adding lactose, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, low-substituted hydroxypropyl cellulose, magnesium stearate and other auxiliary materials, and granulating by means of a fluidized bed to obtain the medicinal solid preparation of tolvaptan.
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