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IMMUNOLOGICAL BIOMARKER FOR PREDICTING CLINICAL EFFECT OF CANCER IMMUNOTHERAPY

机译:预测癌症免疫治疗临床效果的免疫学生物标志物

摘要

The present invention relates to the prediction of responsiveness to cancer immunotherapy of a subject based on the T-cell composition of the subject, and a therapeutic method using cancer immunotherapy based on the prediction. The present invention also provides a method for improving or maintaining responsiveness to cancer immunotherapy of a subject. Responsiveness to cancer immunotherapy is predict by determining a relative value of a CD4. T-cell subpopulation, dendritic cell subpopulation, and/or CD8+ T-cell subpopulation correlated with a dendritic cell stimulation in an anti-tumor immune response in a sample derived from a subject. A composition for treating or preventing cancer comprising cells such as CD62LlowCD4+ T-cells is also provided.
机译:本发明涉及基于受试者的T细胞组成预测受试者对癌症免疫治疗的反应性,以及使用基于该预测的癌症免疫治疗的治疗方法。本发明还提供了一种用于改善或维持受试者对癌症免疫治疗的反应性的方法。通过测定CD4的相对值来预测癌症免疫治疗的反应性。T细胞亚群、树突状细胞亚群和/或CD8+T细胞亚群与来自受试者的样本中抗肿瘤免疫反应中的树突状细胞刺激相关。还提供了一种用于治疗或预防癌症的组合物,其包含诸如CD62LlowCD4+T细胞的细胞。

著录项

  • 公开/公告号EP3580569B1

    专利类型

  • 公开/公告日2022-03-09

    原文格式PDF

  • 申请/专利权人 SAITAMA MEDICAL UNIVERSITY;

    申请/专利号EP20180708226

  • 发明设计人 KAGAMU HIROSHI;

    申请日2018-02-06

  • 分类号G01N33/574;

  • 国家 EP

  • 入库时间 2022-08-24 23:47:53

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