PROBLEM TO BE SOLVED: To provide methods of detecting the signature of Alzheimer's disease before the clinical onset of the disease, such as methods of diagnosing Mild Cognitive Impairment (MCI), monitoring the progress of MCI, and predicting the time to clinical onset of AD dementia.;SOLUTION: A method of diagnosing Mild Cognitive Impairment (MCI) in a subject comprises: (a) obtaining one or more cells from a subject; (b) determining an output signal of one or more diagnostic biomarkers using the one or more cells from the subject, where the diagnostic biomarker is chosen from an AD Index Biomarker, Morphometric Imaging Biomarker and PKC Epsilon Biomarker; and (c) comparing the output signal determined in step (b) to output signals of the diagnostic biomarker for age-matched control (AC) cells and for AD cells.;SELECTED DRAWING: None;COPYRIGHT: (C)2022,JPO&INPIT
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