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NKT cell subset for in vivo survival and therapeutic activity and its proliferation

机译:NKT细胞亚群对体内生存和治疗活性及其增殖的影响

摘要

PROBLEM TO BE SOLVED: To provide a method and composition for producing natural killer T (NKT) cells effective for immunotherapy, and a method and composition for providing an effective amount of NKT cells to an individual in need of immunotherapy. do. NKT cells are CD62L + and are exposed to one or more co-stimulators to maintain the expression of CD62L. In some cases, NKT cells may be engineered to integrate chimeric antigen receptors. [Selection diagram] FIG. 3A
机译:需要解决的问题:提供一种用于产生对免疫治疗有效的自然杀伤T(NKT)细胞的方法和组合物,以及一种用于向需要免疫治疗的个体提供有效数量的NKT细胞的方法和组合物。做NKT细胞为CD62L+,暴露于一种或多种共刺激物中以维持CD62L的表达。在某些情况下,NKT细胞可能被改造成整合嵌合抗原受体。[选择图]图3A

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