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CORONAVIRUS-SPECIFIC T CELL RECEPTOR FUSION CONSTRUCTS, VECTORS ENCODING THE SAME, T CELLS COMPRISING THE SAME AND USES THEREOF
CORONAVIRUS-SPECIFIC T CELL RECEPTOR FUSION CONSTRUCTS, VECTORS ENCODING THE SAME, T CELLS COMPRISING THE SAME AND USES THEREOF
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机译：冠状病毒特异性T细胞受体融合构建体，编码该融合构建体的载体，包含该融合构建体的T细胞及其用途
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摘要
The present invention is inter alia concerned with a T cell receptor fusion construct comprising two specific peptidic moieties, one of these two moieties binding to the spike protein from coro- naviruses and binding to ACE2, in particular the spike proteins from SARS-CoV-2 and/or SARS- CoV-1, and one of these moieties being a protein of the T cell receptor complex. A vector comprising the genetic information encoding the T cell receptor fusion construct is also part of the present invention, as well as a process of transfecting or transducing T cells and a modified T cell comprising the T cell receptor fusion construct. Importantly, the present invention also relates to a T cell receptor fusion construct, a vector or a modified T cell for use in the treatment of a disease and in particular for use in the treatment of a disease caused by a coronavirus such as e.g. COVID-19 or SARS.
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