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PH20 Pharmaceutical composition comprising human hyaluronidase PH20 variant and drug for subcutaneous injection
PH20 Pharmaceutical composition comprising human hyaluronidase PH20 variant and drug for subcutaneous injection
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机译：PH20制药成分组成的人类透明质酸酶PH20变体和药物皮下注射
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摘要
The present invention relates to a pharmaceutical composition comprising (a) a drug and (b) a human PH20 variant. The human PH20 variant included in the pharmaceutical composition according to the present invention is an alpha helix 8 sequence (S347 to C381) in wild-type human PH20 having the amino acid sequence of SEQ ID NO: 1, and a linking site between alpha helix 7 and alpha helix 8 (A333 to R346) ) comprising an amino acid substitution at one or more sites selected from, and characterized in that the amino acid located at the N-terminal or C-terminal portion is selectively cleaved. In addition, the pharmaceutical composition according to the present invention may further include a pharmaceutically acceptable additive, particularly a stabilizer. The pharmaceutical composition according to the present invention can maximize the therapeutic effect of the drug used together due to the effect of the human PH20 variant.
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