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DPP4 Transgenic mouse expressing human DPP4 gene susceptible for South Korean strain Middle East respiratory syndrome coronavirus infection and use thereof
DPP4 Transgenic mouse expressing human DPP4 gene susceptible for South Korean strain Middle East respiratory syndrome coronavirus infection and use thereof
The invention relates to a type plasmic conversion mouse for systemic discovery of human dipeptidyl peptidase4 (human DPP4, hdpp4) gene of coronavirus infection receptor of Middle East respiratory syndrome.More specifically, CMV promoter;Human DPP4 gene;Flag peptide was labeled at the C-terminal to express the human DPP4 gene that can initiate the connection and convert it into form,In order to discover the shape and quality conversion mouse of human DPP4 gene,The invention relates to a method for manufacturing the shape quality conversion mouse.The above shape quality conversion mouse of the invention confirms the discovery of hdpp4 gene and the specific susceptibility of Korean and European Middle East respiratory syndrome coronavirus.Hdpp4 vaginal transfer mice infected with Middle East respiratory syndrome coronavirus showed rapid weight loss and death in the late stage of infection, and severe lung injury was observed.In addition, the sharp secretion of various inflammatory lidocaine was confirmed in hdpp4 vaginal metastasis mice infected with Middle East respiratory syndrome coronavirus.According to the invention, the hdpp4 whole-body visible vaginal transfer mouse can be used as an important animal model for in vivo research to identify the development of Middle East respiratory syndrome coronavirus infectious diseases, and is very useful for developing vaccines and therapeutic agents to control Middle East respiratory syndrome coronavirus.
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