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PREPARATION METHOD FOR EXOSOME-LOADED POLYMER FOR USE IN ORAL COLON-TARGETING DRUG DELIVERY
PREPARATION METHOD FOR EXOSOME-LOADED POLYMER FOR USE IN ORAL COLON-TARGETING DRUG DELIVERY
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机译：EXOSOME-LOADED聚合物的制备方法使用口服COLON-TARGETING药物输送
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摘要
A preparation method for an exosome-loaded self-assembled polymer for use in oral colon-targeting drug delivery. The polymer is formed by compounding chitosan quaternary ammonium salt (HTCC), oxidized konjac glucomannan (OKGM), and a mesenchymal stem cell-derived exosome (MSCs-EXO) by means of layer-by-layer (LBL) wrapping and LBL encapsulation. The polymer has certain biocompatibility, stability, safety, anti-inflammatory, and sustained release performance, and can be used as a drug-carrying system to carry the exosome so as to repair an ulcerous part.
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