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首页> 外文会议>12th Romanian International Conference on Chemistry and Chemical Engineering Sep 13-15, 2001 Bucharest, Romania >Aminated polysaccharide microsphere as support for DNA transport in gene therapy
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Aminated polysaccharide microsphere as support for DNA transport in gene therapy

机译：胺化多糖微球在基因治疗中支持DNA转运

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摘要

The aim of this work is the production and characterization of cationic micropartictes based on pullulan and starch for the delivery of nucleic acids.. The microparticles were prepared by chemically cross-linkinking with epichlorohydrin of an aqueous polymer solution dispersed in organic phase, followed by amination with N,N-diethyl-2-chIoroethyl amine hydrochloride or N-glyeidyl-N,N-dimethyl-N-methylammonium chloride. The association capacity and the affinity of microspheres for DFT were investigated in relation to the type of polysaceharide, the content and the basicity of aminogroups. It was found that the both types of synthetized carriers display a high affinity for Defibrotide due to the high porosity of polysaccharide microspheres.
机译：这项工作的目的是生产和表征基于支链淀粉和淀粉的用于递送核酸的阳离子微粒。通过与环氧氯丙烷化学交联使分散在有机相中的聚合物水溶液形成微粒，然后进行胺化用N，N-二乙基-2-氯代乙胺盐酸盐或N-缩水甘油基-N，N-二甲基-N-甲基氯化铵。考察了聚砜的类型，氨基含量和碱性对微球对DFT的缔合能力和亲和力。发现由于多糖微球的高孔隙率，两种类型的合成载体对去纤蛋白显示出高亲和力。

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