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首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >Emulsion Crosslinking as a New Manufacturing Route to Produce Hydroxylapatite Particulates in a Network of Starch
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Emulsion Crosslinking as a New Manufacturing Route to Produce Hydroxylapatite Particulates in a Network of Starch

机译：乳液交联作为生产羟基磷灰石颗粒的新制造途径在淀粉网络中

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摘要

Bioactive particulates with tailored resorption rates can be very useful on biomedical applications such as filling of bone and dentristy defects, carriers for controlled release of bioactive agents and reinforcement in polymer/bioceramic orthopaedic composites. The aim of the present study was to develop a new processing route to produce composite particulates based on hydroxylapatite (HA) and starch. The newly proposed processign route consists on the crosslinking of starch that is able to encapsulate the HA particles creating a composite material with different sizes (from 3000-700 mum) which is resorbable and bioactive. This work also involves the characterization of the developed material, as well as the study of the in-vitro degradation and bioactive behaviour of the particulates. The particulate biomaterials have shown to be bioactive even after small immersion periods on a simulated body fluid (SBF). The obtained results (in-vitro) indicate that particulates will be expected to be resorbed when implanted. The developed materials present an interesting combination of morphological and chemical properties that make them potential biomaterials to be used as fillers of bone defects, drug delivery carriers or as reinforcement of bioactive starch-based composites.
机译：具有定制吸收率的生物活性颗粒可在生物医学应用中非常有用，例如骨骼和牙齿缺损的填充，可控制释放生物活性剂的载体以及增强聚合物/生物陶瓷矫形复合材料。本研究的目的是开发一种新的工艺路线，以生产基于羟磷灰石（HA）和淀粉的复合颗粒。新近提出的加工途径是淀粉交联，该交联能够包裹HA颗粒，从而形成具有不同大小（3000-700微米）的可吸收和生物活性的复合材料。这项工作还涉及开发材料的表征，以及颗粒的体外降解和生物活性行为的研究。颗粒状生物材料即使在模拟体液（SBF）上短暂浸入一段时间后也具有生物活性。所获得的结果（体外）表明，植入后有望吸收颗粒。所开发的材料呈现出有趣的形态和化学特性组合，使其成为潜在的生物材料，可用作骨缺损的填充物，药物输送载体或生物活性淀粉基复合材料的增强材料。

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