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首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >Enhanced Surface and Mechanical Properties of Nanophase Ceramics to Achieve Orthopaedic/Dental Implant Efficacy
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Enhanced Surface and Mechanical Properties of Nanophase Ceramics to Achieve Orthopaedic/Dental Implant Efficacy

机译：增强纳米相陶瓷的表面和力学性能，以达到骨科/牙科植入物的功效

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摘要

Alumina, titania, and hydroxyapatite substrates (with nanophase grain sizes less than 100 nm and conventional grain sizes greater than 100 nm) were synthesized and evaluated for mechanical and cytocompatibility properties pertaining to orthopaedic/dental applications. Results demonstrated that nanophase ceramics possess mechanical (specifically, ductility) and surface properties (namely, topography and wettability) that are desirable and have the potential to achieve orthopaedic/dental implant efficacy. Compared to conventional ceramic formulations, the average bending moduli of nanophase ceramics were significantly less and, thus, close to the modulus of human femur bone. Moreover, compared to conventional ceramics, osteoblast (the bone-formation cells) adhesion increased while fibroblast (cells that contribute to fibrous encapsulation and callus formation events which may lead to implant loosening and failure) adhesion decreased on all nanophase ceramics tested. Our studies also provided the first evidence of enhanced long-term (on the order of days to weeks) functions (specifically, proliferation, synthesis of alkaline phosphatase and deposition of calcium-containing mineral) of osteoblasts cultured on nanophase ceramics. Nanometer grain-size topography and surface wettability are nanoceramic material properties that not only promote increased select adsorption of vitronectin (a protein that mediates osteoblast adhesion) but also effect conformation(s) that enhanced, subsequent, osteoblast functions. Such nanoceramic properties constitute design parameters that should be incorporated into the next generation of orthopaedic/dental implant materials with improved osseointegrative properties.
机译：合成了氧化铝，二氧化钛和羟基磷灰石基底（纳米相晶粒尺寸小于100 nm，常规晶粒尺寸大于100 nm），并评估了与骨科/牙科应用相关的机械和细胞相容性。结果表明，纳米相陶瓷具有理想的机械性能（特别是延展性）和表面性能（即形貌和润湿性），并具有实现骨科/牙科植入物功效的潜力。与传统的陶瓷配方相比，纳米相陶瓷的平均弯曲模量明显更低，因此接近人类股骨的模量。此外，与常规陶瓷相比，在所有测试的纳米陶瓷上，成骨细胞（骨形成细胞）的粘附力均增加，而成纤维细胞（有助于纤维包封和愈伤组织形成事件，可能导致植入物松动和破坏的细胞）的粘附力降低。我们的研究还提供了增强纳米相陶瓷上培养的成骨细胞长期（数天至数周）功能（特别是增殖，碱性磷酸酶合成和含钙矿物沉积）的证据。纳米粒度的形貌和表面润湿性是纳米陶瓷材料的特性，不仅促进玻连蛋白（介导成骨细胞粘附的蛋白质）的选择性吸附增加，而且还影响构象，从而增强随后的成骨细胞功能。此类纳米陶瓷特性构成了设计参数，应将其结合到具有改善的骨整合特性的下一代骨科/牙科植入材料中。

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