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首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >Basic Properties of Apatite Cement Containing Carbonate Apatite and Its Resorption by Cultured Osteoclasts
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Basic Properties of Apatite Cement Containing Carbonate Apatite and Its Resorption by Cultured Osteoclasts

机译：含碳磷灰石的磷灰石水泥的基本性能及其对破骨细胞的吸收

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摘要

Apatite cement (AC) has received much attention as a new reconstructive material for bony defects because AC transforms to hydroxyapatite (HAP) and shows excellent tissue response and osteoconductivity. In addition, AC has been reported to be partly replaced with bone, although the process takes a long time. The aim of this study, therefore, is to fabricate bone-replacing apatite cement by converting AC to be easily resorbed by osteoclasts. For this purpose, NaHCO_3 was added into the AC component. The amount of CO_3 incorporated into the set AC increased with the amount of added NaHCO_3. B-type carbonate apatite (CO_3-AP) was formed in the set AC added NaHCO_3. The dissolution rate of the set AC in weak acid, pH 5.5, increased with NaHCO_3. The number of resorption pits and the resorbed area by cultured osteoclasts increased with added CO_3 content. The resorbed area on 4percent CO_3-added-AC was twice as much as that of carbonate-free-AC. The results suggested that CO_3-AP-formed AC would be easily resorbed by osteoclasts.
机译：磷灰石水泥（AC）作为一种新型的骨缺损重建材料受到了广泛的关注，因为AC可以转变为羟基磷灰石（HAP），并具有出色的组织反应性和骨传导性。另外，据报道，尽管AC过程需要很长时间，但AC已被骨骼部分替代。因此，本研究的目的是通过将AC转化为易于被破骨细胞吸收的材料来制造可替代骨的磷灰石水泥。为此，将NaHCO_3添加到AC组件中。掺入组AC中的CO_3的量随添加的NaHCO_3的量而增加。在添加有AC的NaHCO_3中形成B型碳酸盐磷灰石（CO_3-AP）。固定的AC在pH 5.5的弱酸中的溶解速率随NaHCO_3的增加而增加。培养的破骨细胞的吸收坑数和吸收面积随CO_3含量的增加而增加。添加4％CO_3的AC的重吸收面积是不含碳酸盐的AC的两倍。结果表明，破骨细胞很容易吸收CO_3-AP形成的AC。

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