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An Experimental Approach to the Study of the Rheology Behaviour of Synthetic Bone Calcium Phosphate Cements

机译:研究合成骨磷酸钙水泥流变行为的实验方法

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摘要

Calcium phosphate cements were developed to fit surgical needs in biomedical fields such as odontology or traumatology. Nowadays, a broad fiel of new applications have been found for this kind of materials. Drug delivery systems, tissue-engineering scaffolds and osteoporotic bone filling applications are some of the new fields that are being benefited with these materials. Looking at both, commercial and new experimental calcium phosphate cements it is found that alpha-tricalcium phosphate is the main reactive powder responsible for the settign and the hardening of the cement. Thus, it is important to know how alpha-tricalcium phosphate affects injectability of these cements. The aim of this study was to investigate the rheological behaviour of alpha-tricalcium phosphate slurries in order to know how the cement injectability should be modified. Factors such as liquid to powder ratio, particle size of the main reacive powder and the addition of dispersants have been considered. The results showed that viscosity decreased when particle size of reactant was increased and when liquid to powder ratio was increased. It was also found that a minimum of viscosity exists at an optimum value of the weight percentage of dispersant.
机译:磷酸钙水泥的开发是为了满足生物医学领域(如牙医学或创伤学)的外科手术需求。如今,已发现此类材料的广泛新应用。药物输送系统,组织工程支架和骨质疏松性骨填充应用是受益于这些材料的一些新领域。从商业和新的实验性磷酸钙水泥来看,发现α-磷酸三钙是负责水泥凝固和硬化的主要反应性粉末。因此,重要的是要知道α-磷酸三钙如何影响这些水泥的可注射性。这项研究的目的是研究α-磷酸三钙浆液的流变行为,以便了解如何修改水泥的可注射性。已经考虑了诸如液体与粉末的比例,主要反应性粉末的粒径以及分散剂的添加等因素。结果表明,当反应物的粒径增加而液粉比增加时,粘度降低。还发现粘度的最小值存在于分散剂的重量百分比的最佳值处。

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