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首页> 外文会议>13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy >Apatite-Forming Ability of Polymers with Carboxy Groups in Simulated Body Fluid
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Apatite-Forming Ability of Polymers with Carboxy Groups in Simulated Body Fluid

机译：模拟体液中含羧基聚合物的磷灰石形成能力

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Apatite-polymer composites with analogous structure to that of the natural bone are desired to be developed, since such composites are beleived to show biological and mechanical properties similar to those of the natural bone. In the present study, apatite-forming ability of various kinds of polymers with or without carboxy (COOH) groups in simulated body fluid (SBF) was investigated. Carboxymethyl- (CM)- chitin and gellan gum gels, which have COOH groups, formed apatite on their surfaces within 3 d, when they were previously treated with saturated Ca(OH)_2 solution. Calcium alginate gel with COOH groups formed apatite on its surface within 7 d without the Ca(OH)_2-treatment, since calcium ions are previously incorporated into the gel structure in the gel-forming process. In contrast, curdlan gel without COOH groups did not form the apatite on its surface within 14 d even after the Ca(OH)_2-treatment. These results indicate that the COOH groups on a polymer surface are effective for the apatite nucleation and the apatiteforming ability of the polymer can be improved by incorporation of the calcium ions. In conclusion, these types of polymers are promising candidates for obtaining apatite-polymer composites with bonelike structure by a biomimetic process.
机译：期望开发具有与天然骨类似的结构的磷灰石-聚合物复合物，因为这样的复合物被认为显示出与天然骨相似的生物学和机械性能。在本研究中，研究了在模拟体液（SBF）中具有或不具有羧基（COOH）的各种聚合物的磷灰石形成能力。事先用饱和Ca（OH）_2溶液处理后，具有COOH基团的羧甲基-（CM）-几丁质和吉兰糖胶在表面3天内形成磷灰石。由于在形成凝胶的过程中事先将钙离子掺入到凝胶结构中，因此具有COOH基团的藻酸钙凝胶在7天内就在其表面形成了磷灰石，而未经Ca（OH）_2处理。相反，即使在经过Ca（OH）_2处理后，没有COOH基团的柯德兰凝胶也未能在14天内在其表面形成磷灰石。这些结果表明，聚合物表面上的COOH基团对于磷灰石成核是有效的，并且通过引入钙离子可以提高聚合物的磷灰石形成能力。总之，这些类型的聚合物是有望通过仿生过程获得具有骨样结构的磷灰石-聚合物复合材料的候选材料。

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