首页> 外国专利> compound, radiopharmaceutical formulation, pharmaceutical composition, use of the compound, mixing, methods of collecting data for the diagnosis of an amyloid-associated disease or condition, determining the extent of amyloidogenic plaque burden in a tissue and / or body fluid, collecting data to determine a predisposition to an amyloid-associated disease or condition in a patient, to collect data to monitor a minimal residual disease in a patient following treatment with an antibody or vaccine composition, to collect data to predict a patient's ability to react. a patient being treated with an antibody or vaccine composition, and, test kit.

compound, radiopharmaceutical formulation, pharmaceutical composition, use of the compound, mixing, methods of collecting data for the diagnosis of an amyloid-associated disease or condition, determining the extent of amyloidogenic plaque burden in a tissue and / or body fluid, collecting data to determine a predisposition to an amyloid-associated disease or condition in a patient, to collect data to monitor a minimal residual disease in a patient following treatment with an antibody or vaccine composition, to collect data to predict a patient's ability to react. a patient being treated with an antibody or vaccine composition, and, test kit.

机译:化合物,放射性药物制剂,药物组合物,该化合物的用途,混合,用于诊断与淀粉样蛋白相关的疾病或状况的数据收集方法,确定组织和/或体液中淀粉样蛋白斑块负担的程度,将数据收集到确定患者中与淀粉样蛋白相关的疾病或病状的易感性,收集数据以监测用抗体或疫苗组合物治疗后患者体内的最小残留疾病,收集数据以预测患者的反应能力。用抗体或疫苗组合物治疗的患者,以及检测试剂盒。

摘要

compound, radiopharmaceutical formulation, pharmaceutical composition, use of the compound, mixing, methods of collecting data for the diagnosis of an amyloid-associated disease or condition, determining the extent of amyloidogenic plaque burden in a tissue and / or body fluid, collecting data to determine a predisposition to an amyloid-associated disease or condition in a patient, to collect data to monitor a minimal residual disease in a patient following treatment with an antibody or vaccine composition, to collect data to predict a patient's ability to react. a patient being treated with an antibody or vaccine composition, and, test kit. The present invention relates to novel compounds which may be used in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as alzheimer's disease and diseases or conditions associated with amyloid-like proteins. The compounds of the present invention may also be used in the treatment of eye diseases associated with pathological abnormalities / changes in visual system tissues. The present invention further relates to pharmaceutical compositions comprising these compounds and the use of these compounds for the preparation of medicaments for the treatment or prevention of diseases or conditions associated with amyloid or amyloid-like protein. A method of treating or preventing diseases or conditions associated with amyloid and / or amyloid-like proteins is also disclosed.
机译:化合物,放射性药物制剂,药物组合物,该化合物的用途,混合,用于诊断与淀粉样蛋白相关的疾病或状况的数据收集方法,确定组织和/或体液中淀粉样蛋白斑块负担的程度,将数据收集到确定患者中与淀粉样蛋白相关的疾病或病状的易感性,收集数据以监测用抗体或疫苗组合物治疗后患者体内的最小残留疾病,收集数据以预测患者的反应能力。用抗体或疫苗组合物治疗的患者,以及检测试剂盒。本发明涉及可用于治疗与淀粉样蛋白有关的一组疾病和异常的新化合物,所述疾病如阿兹海默氏病和与淀粉样蛋白有关的疾病或病状。本发明的化合物也可用于治疗与病理异常/视觉系统组织改变有关的眼部疾病。本发明进一步涉及包含这些化合物的药物组合物,以及这些化合物在制备用于治疗或预防与淀粉样蛋白或淀粉样蛋白有关的疾病或病症的药物中的用途。还公开了一种治疗或预​​防与淀粉样蛋白和/或淀粉样蛋白有关的疾病或病症的方法。

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