AMERICAN FILTRATION AND SEPARATIONS SOCIETYTECHNICAL CONFERENCE

机译：美国过滤与分离学会技术会议

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The biotechnology industry has evolved as a revolutionary process with the potential ofrndramatically improving the overall quality of life, spanning health care, agriculturalrnproducts and industrial chemicals. However along with this potential is the enormousrnpressure to develop efficient, cost-effective products that achieve the goals asrnpromised.rnCross-flow membrane filtration offers tremendous opportunities to the biotechnologyrnindustry in being able to accomplish very distinct separations and purifications, resultingrnin significant advancements in both product development and quality.rnThe unique advantages that membrane technology offers are in its ability to achievernspecific fractionations of high value products in applications such as cell harvesting,rnprotein isolation and concentration and drug purification. In many cases, the results arernextremely high purity of these products at much higher yields and lower operating costsrnthan traditional separation methods such as centrifugation, rotary vacuum filters andrnfilter presses.rnThe effective design of the membrane system itself is a critical factor to enable thernprocessor to take full advantage of these potential benefits. This presentation willrnaddress the more prominent considerations that are used in the design of thernmembrane plant.rnThe design of the membrane system will greatly depend on the specific properties of thernultimate product being harvested or processed. The key properties of the products thatrnimpact the system design are:Stability of the productrnShear sensitivityrnVolume of product to be processedrnUpstream and downstream operation steps Taking these factors into consideration, the steps in the design process will thenrninclude:Review of System Design Criteria, such as:GMP compliancern3A sanitary standardsrnSpecific requirements, I.e. Explosion Proof Pilot Testing Compiling and review of datarnScale Up

机译：生物技术产业已经发展成为一个革命性的过程，具有极大地改善人们的整体生活质量的潜力，涉及医疗保健，农产品和工业化学品。然而，伴随着这种潜力的是巨大的压力，需要开发出能够实现既定目标的高效，具有成本效益的产品。错流膜过滤为生物技术行业提供了巨大的机会，使其能够完成截然不同的分离和纯化，从而导致两种产品的重大进步膜技术的独特优势在于能够在诸如细胞收获，蛋白质分离和浓缩以及药物纯化等应用中实现高价值产品的特定分级分离。在许多情况下，与传统的分离方法（例如离心，旋转真空过滤器和压滤机）相比，结果是这些产品的纯度极高，产率高得多，运行成本也低。膜系统本身的有效设计是使处理器能够采用的关键因素。这些潜在利益的全部优势。该演讲将解决在膜工厂设计中使用的更为突出的考虑。膜系统的设计将在很大程度上取决于要收获或加工的最终产品的特殊性能。影响系统设计的产品的关键特性包括：产品的稳定性-剪切敏感性-要处理的产品的数量-上游和下游操作步骤考虑到这些因素，设计过程中的步骤将包括：审查系统设计标准，例如： GMP符合性3A卫生标准特殊要求，即防爆试验测试数据的汇编和审查

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《16th Annual technical conference and exposition of the American Filtration and Separations Society》|2003年|1-12|共12页
会议地点 Reno NV(US)
作者
BOB KEEFE;
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作者单位

MARKET MANAGER, BIOTECH/PHARMArnNIRO INC.rn1600 O’KEEFE ROADrnHUDSON, WI 54016rnTELEPHONE: 715-386-0176rnTELEFAX: 715-386-9376rnE-MAIL: rjk@geafiltration.com;

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中图分类油气田开发与开采;
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1. American Filtration and Separations Society to Hold Water Filtration and Filter Testing Conference [J] . Filtration news . 2010,第4期

机译：美国过滤与分离学会举行水过滤与滤池测试会议
2. American Filtration and Separations Society to Hold 23nd Annual Technical Conference [J] . Filtration news . 2010,第2期

机译：美国过滤与分离学会召开第二十三届年度技术会议
3. AMERICAN FILTRATION AND SEPARATIONS SOCIETY 21st ANNUAL TECHNICAL CONFERENCE [J] . Filtration Group FILTRATION . 2008,第2期

机译：美国过滤与分离学会第21届年度技术会议
4. American Filtration and Separation Society, 2011 Spring Conference Filtration Innovation for a Cleaner World [C] . Chuanfang(Ted) Yang, Andrew J. Dallas, Debra L Wilfong American Filtration and Separations Society annual conference . 2012

机译：美国过滤与分离学会，2011年春季会议过滤创新为更清洁的世界
5. Modification of formed-in-place microfiltration membranes for specific protein separations and fundamental studies of affinity membrane separation processes and protein-ligand interactions. [D] . Li, Yuhua. 1994

机译：用于特定蛋白质分离的原位微滤膜的修饰以及亲和膜分离过程和蛋白质-配体相互作用的基础研究。
6. Health developments in rural America 1953. A conference report on the American Medical Associations eighth National Conference on Rural Health [O] . 1953

机译：1953年美国农村地区的健康发展。美国医学会第八届全国农村健康大会的会议报告
7. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation31This document was approved by the American College of Cardiology Board of Trustees in August 2001, the American Heart Association Science Advisory and Coordinating Committee in August 2001, and the European Society of Cardiology Board and Committee for Practice Guidelines and Policy Conferences in August 2001.32When citing this document, the American College of Cardiology, the American Heart Association, and the European Society of Cardiology would appreciate the following citation format: Fuster V, Rydén LE, Asinger RW, Cannom DS, Crijns HJ, Frye RL, Halperin JL, Kay GN, Klein WW, Lévy S, McNamara RL, Prystowsky EN, Wann LS, Wyse DG. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation). J Am Coll Cardiol 2001;38:XX-XX.33This document is available on the World Wide Web sites of the American College of Cardiology (www.acc.org), the American Heart Association (www.americanheart.org), the European Society of Cardiology (www.escardio.org), and the North American Society of Pacing and Electrophysiology (www.naspe.org). Single reprints of this document (the complete Guidelines) to be published in the mid-October issue of the European Heart Journal are available by calling +44.207.424.4200 or +44.207.424.4389, faxing +44.207.424.4433, or writing Harcourt Publishers Ltd, European Heart Journal, ESC Guidelines – Reprints, 32 Jamestown Road, London, NW1 7BY, United Kingdom. Single reprints of the shorter version (Executive Summary and Summary of Recommendations) published in the October issue of the Journal of the American College of Cardiology and the October issue of Circulation, are available for $5.00 each by calling 800-253-4636 (US only) or by writing the Resource Center, American College of Cardiology, 9111 Old Georgetown Road, Bethesda, Maryland 20814. To purchase bulk reprints specify version and reprint number (Executive Summary 71-0208; full text 71-0209) up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 214-706-1466, fax 214-691-6342; or E-mail: pubauth@heart.org. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the North American Society of Pacing and Electrophysiology [O] . Fuster Valentin, Rydén Lars E., Asinger Richard W., 2001

机译：ACC / AHA / ESC治疗房颤患者指南31该文件于2001年8月获得美国心脏病学会董事会，2001年8月美国心脏协会科学咨询与协调委员会以及欧洲心脏病学会的批准以及实践指南和政策委员会会议（2001年8月）。32引用本文件时，美国心脏病学会，美国心脏协会和欧洲心脏病学会将赞赏以下引用格式：Fuster V，RydénLE，Asinger RW，Cannom DS，Crijns HJ，Frye RL，Halperin JL，Kay GN，Klein WW，LévyS，McNamara RL，Prystowsky EN，Wann LS，Wyse DG。 ACC / AHA / ESC治疗房颤患者的指南：美国心脏病学会/美国心脏协会实践指南工作组和欧洲心脏病学会实践指南委员会和政策会议的报告（制定指南委员会）用于房颤患者的治疗）。 J Am Coll Cardiol 2001; 38：XX-XX.33本文件可在美国心脏病学会（www.acc.org），美国心脏协会（www.americanheart.org），欧洲的万维网站点上找到心脏病学会（www.escardio.org）和北美起搏和电生理学会（www.naspe.org）。可致电+44.207.424.4200或+44.207.424.4389，传真+44.207.424.4433或写信给Harcourt Publishers，以获取本文档（完整的准则）的单份重印本（完整的准则），该印刷本将于10月中旬出版。欧洲心脏杂志，ESC指南–转载，英国伦敦詹姆斯敦路32号，NW1 7BY。短版（执行摘要和建议摘要）的单版重印在《美国心脏病学会杂志》十月刊和《循环》十月刊上，致电800-253-4636（仅美国），每本售价5.00美元。）或写信给美国心脏病学院资源中心，地址是：马里兰州贝塞斯达市Old Georgetown Road 9111，邮编20814。要购买批量转载，请指定版本和转载编号（执行摘要71-0208；全文71-0209），最多999份，致电800-611-6083（仅限美国）或传真413-665-2671； 1000或更多副本，请致电214-706-1466，传真214-691-6342;或电子邮件：pubauth@heart.org。美国心脏病学会/美国心脏协会实践指南工作组和欧洲心脏病学会实践指南和政策会议（制定房颤患者治疗指南委员会）的报告是与北方合作开发的美国起搏与电生理学会

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